Instructor
Dr. Gregory Underhill
gunderhi@illinois.edu
Office: 2112 Everitt Lab
217-244-2169
Office Hours: Email Appointment
Description
Principles underlying tissue structure-function relationships. Engineering methods for manipulating cellular environments. Quantitative cell and tissue characterization. Design and clinical translation of cell-based therapies.
Class meets TR 9:30-10:50am in 2310 Everitt Lab.
Course Objectives
- (a) an ability to apply knowledge of mathematics, science, and engineering
- (b) an ability to design and conduct experiments, as well as to analyze and interpret data
- (c) an ability to design a system, component, or process to meet desired needs within realistic constraints such as economic, environmental, social, political, ethical, health and safety, manufacturability, and sustainability
- (d) an ability to function on multidisciplinary teams
- (e) an ability to identify, formulate, and solve engineering problems
- (f) an understanding of professional and ethical responsibility
- (g) an ability to communicate effectively
- (h) the broad education necessary to understand the impact of engineering solutions in a global, economic, environmental, and societal context
- (j) a knowledge of contemporary issues
- (j) a knowledge of contemporary issues
Required Textbook
None.
Reading material will be assigned from a combination of book chapters, review articles, and primary research papers.
Grading
Exams
Two midterms (6th and 12th week of the semester). Midterms are closed-book exams during the normal lecture period.
Project
Students will organize into groups of approximately 5 students, select a tissue-engineering topic from a list provided, and prepare a proposal that designs an experiment to test a novel tissue engineering approach. Writing guidelines will be provided at a later date. Groups will also prepare presentations of their design, to be presented during class.
Homeworks/In-Class Exercises
- Approximately 5-6 homework sets based on lectures and assigned reading material.
- In class assignments and discussions.
Note: Students may discuss homework problems, but students must complete their own work and write up solutions independently.
In-Class Quizzes
Approximately 10 pop quizzes will be given throughout the semester (roughly 1 per week, excluding project presentation weeks). These quizzes will be given at the beginning of the lecture period. The 2 lowest quiz grades will be dropped from the total quiz grade. A missed quiz due to absence or late attendance will count as one of these dropped quizzes.
Grading
Homeworks/In-Class Exercises 24%
In-Class Quizzes 5%
Midterm #1 24%
Midterm #2 24%
Project Presentation 10%
Project Proposal 13%
Letter grade determination:
>97% = A+; >93% = A; >89.5% = A-; >87% B+; >83% = B; >79.5% = B-; >77% = C+; >73% = C; >67% = C-
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Week Of |
Tuesday |
Thursday |
Homework Due |
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8/27 |
Introduction: Tissue Engineering and Cell-Based Therapies |
Tissue Organization Reading: paper 1 (read for Tues. 9/4) |
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9/3 |
Tissue Morphogenesis |
Tissue Dynamics Reading: chapter (read for Tues. 9/11) |
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9/10 |
Stem Cells and Lineages |
Cell Isolation and Culture |
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9/17 |
Cell-Cell Communication |
ECM and Natural Scaffold Materials Reading: chapter (read for Tues. 9/25) |
Homework #1 Due Tuesday 9/18 (in class) Homework #1 Solutions |
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9/24 |
Synthetic Biomaterial Scaffolds Reading: paper (read for Thurs. 9/27) |
Scaffold Fabrication & Tailoring |
Homework #2 Due Thursday 9/27 (in class) Homework #2 Solutions |
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10/1 |
Project Introduction- Review |
Midterm #1: Weeks 1-5 Quiz #1 solutions Quiz #2 solutions Quiz #3 solutions Quiz #4 solutions In-Class Sample Questions & Solutions |
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10/8 |
Graft Rejection/Material Biocompatibility |
Controlled Release/Drug Delivery Reading: paper (read for Tues. 10/16) |
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10/15 |
Vascularization |
No Lecture |
Homework #3 Due Tuesday 10/16 (in class) Homework #3 Solutions |
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10/22 |
Cell Migration Readings and Associated Questions- To be Discussed (Thurs. 10/25) |
Cell Mechanics |
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| 10/29 |
Microtechnology Tools I |
Microtechnology Tools II |
Homework #4 Due Tuesday 10/30 (in class) Homework #4 Solutions |
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11/5 |
Engineered Disease Models | Stem Cell Therapies |
Homework #5 (Project Draft Summary) Due Thursday 11/8 (in class) |
| 11/12 |
Case Study |
Midterm #2 Weeks 7-12 Quiz #5 Solutions Quiz #6 Solutions Quiz #7 Solutions Quiz #8 Solutions Quiz #9 Solutions Quiz #10 Solutions Exam- Example Topics to Review In-Class Sample Questions & Solutions |
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| 11/19 |
Thanksgiving Break |
Thanksgiving Break |
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| 11/26 |
Project Details Tissue Engineering Ethics |
No Lecture Project Discussion Meetings |
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| 12/3 |
Project presentations Group #1: Microscale Tissue Engineering: Brittany Amawan, Avani Patel, Nicole Lima, Lauren Grove, Molly Fay Group #2: Artificial Cornea: Rodrigo Diaz, Monica Mastalerz, Stephanie Zimbru, Vincent Cornelius, Tarun Nagarajan Group #3: Organ-on-a-Chip: Kiran Murphy, Devrina Chidambaram, Shubhangi Joshi, Yitong Yang, Nikita Mandhan Group #4: Traumatic Brain Injury: Claire Niewiara, Ana Rivero Valles, Young Huh, Suyeon Kim, Yujin Lee Group #5: Epimorphic Limb Regeneration: Krista Habing, Heather Zelko, Kendall Junger, Monika Kizerwetter, Jackie O'Connor |
Project presentations Group #6: Skeletal Muscle: Rohail Bhurgri, Bri Sarley, Mary Figura, Sherri Ho, Joshua Au Group #7: Bioartificial Kidney: Hannah Meiselman, Sisi He, Simon Egner, Shannon D'Souza, Manasa Bolla Group #8: Facial Reconstruction: Kajsa Chen, Jason Wu, Eamon Bracht, Luke Ang, Justin Tao Group #9: Spinal Cord: Nathan Apter, Faisal Masood, Vignesh Alla, Ben David, Craig Soares Group 10: Engineerd Tumor: Catherin Applegate, Kelsey Finnamore, Benjamin Liang, Sohil Amin, Bashar Emon
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12/10 |
Project presentations Group 11: Responsive Scaffolds: William Spreadbury, Monet Worsham, David Zhong, Pranav Ghatraju, Noah Simon Group 12: Ligament: Jonathan Cruz, Ramon Macias, Jacob Foster, Kyle Ritchie Group 13: Heart Patch: Lauren Pritz, Nikita Tummalapalli, Diana Slater, Alicia Barker, Andrea Daniel Group 14: Lymphatics: Denzel Ryan Cruz, Amelia Cornman, James Liu, Carlos Garcia, Tej Patel Group 15: Cartilage: Luie Siegel, Victor Pastrana-Gomez, Young Gi Moon, Jared Lund, Reid Jockisch
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Exam Week |
Written Proposal Due: 5pm Wednesday 12/19 (1 copy per group, emailed to Prof. Underhill) |
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