BIOE 498 | MCB 493 | ME 498
BioNanotechnology and Nanomedicine: Applications in Cancer and Mechanobiology
Fall 2014



Course Information

Information about the R21 Proposal Review Assignment and the R21 Proposals can be found here.

Teams have been assigned! Please see the *updated* list here (Sept 23).

   If your group number is odd, you present on Tuesday, October 21.

   If your group number is even, you present on Thursday, October 23.

Course syllabus

Classes: Tuesdays and Thursdays, 3:30-4:50 PM; 1105 Siebel Center
Credit: 3 hours (undergraduate) or 4 hours (graduate)
Prerequisites:  MCB 150 or equivalent knowledge

Instructor: Dr. Andrew Smith
Office Hours: Mondays, 1:30-2:30pm & Fridays 1:00-2:00pm
Location: 3114 Micro and Nanotechnology Laboratory

Graduate Teaching Assistant: Mohammad Zahid
Office Hours: Mondays, 4-5pm & Tuesdays, 12:30-1:30pm
Location: 3003 Micro and Nanotechnology Laboratory

Textbook:  There is no required textbook. Research articles will be provided during the course.
The following suggested reference texts are on reserve at the Grainger Engineering Library:
- The Biology of Cancer, 2nd ed., by Robert Weinberg (Garland Science 2014).
- Principles of Cancer biology, by Lewis Kleinsmith (Cummings 2006).
- The Emperor of All Maladies: A Biography of Cancer, by Siddhartha Mukherjee (Scribner 2011).


The objective of this course is to understand basic concepts in the application of nanotechnology to cancer and mechanobiology. A major goal is for students to become comfortable integrating principles from multiple disciplines of physics, chemistry, engineering, mechanics, and biology toward generating new strategies for understanding, detecting, and treating cancer. This course is targeted for first year graduate students and senior level undergraduate students.


This course has 4 components

1. Fundamentals of cancer biology and limitations of clinical oncology
2. Introduction to "bottom-up" nanotechnology and nanomedicine
3. Introduction to "top-down" nanotechnology and microfluidics
4. Applications in cellular mechanics

This is a "flipped" class! This means that you are expected to prepare for each class period in advance! You should do the following prior to each class period:

1. Study the lecture slides. Focus on the core concepts emphasized in advance.
2. Watch the lecture from previous course years on the topic.
3. Read any additional materials assigned.

During class we will:

1. Discuss the assigned reading and slides and answer questions.
2. Work on assignments and problems that will be turned in during the next class period.
3. Work on the R21 proposal in groups.
Your grade will be determined by the total points earned from the following:
Homeworks: 15%
Quizzes: 35%
Proposal: 25% (reviewed by others)
Proposal: 25% (reviewed by faculty)
Statement on Academic Integrity

The University's policy on academic integrity can be found in the Code of Policies and Regulations Applying to All Students under Article One, Part IV. The following policies support and reinforce that policy.

1. Science cannot exist without honesty. We expect all students, as scientists-in-the-making, to hold the highest standards of scientific and academic conduct. Any form of cheating on any graded work in this course is unacceptable, and will be dealt with as outlined below, and in accordance with the University-wide standards in the Code of Policies and Regulations Applying to All Students.

2. We require that all graded work be entirely your own, and that anything you write using the words of other writers be correctly attributed. Some specific points follow:

On assignments, quizzes, and presentations, the answers that you turn in for grading must be your own understanding of the material. Even working within a group, you must contribute to the group's effort and not just have one person do all of the work. Since we cannot monitor you as you complete your work, we have only the appearance of your work from which to judge. If the work that you submit closely resembles that of another student/team too closely, we may conclude that it was not your original work. Failure to adhere to these standards may result in a grade of zero for the entire assignment, for all persons involved.

On assignments, if you use another source to obtain the facts and/or opinions necessary to complete your assignment, you must credit the source (see next point below) and rephrase the information so that your assignment is entirely your own words. A good practice is to read the source until you have a thorough understanding of the material, and then put it away. Write your assignment as if you are explaining the information you learned from reading the source to a classmate, member of your family, or to your teaching assistant. You may wish to look at the source again for clarification, but be certain that you do not use statements taken directly from the text in your assignment. Your entire assignment should be in your own words. Furthermore, paraphrasing does NOT mean replacing key words in a statement with synonyms. For an example of proper paraphrasing of a statement, consult the University's Code of Policies and Regulations Applying to All Students.

Failure to adhere to these standards may result in zero credit for the entire assignment.

On assignments, if you use the ideas and/or opinions from another author or source, you must provide the appropriate citation. That is, you must, using APA format, place a parenthetical reference to the source that provided you the information necessary to complete that portion of the assignment.

Failure to adhere to these standards may result in zero credit for the entire assignment.

On assignments, if you use a statement taken directly from any book or other publication, including the course textbook, you must provide a citation. That is, you must put the text in quotes and, using APA format, place a parenthetical reference to the source at the end of the quote. Direct quotations should be severely limited in your assignment; they should be used ONLY in the following situations:

Furthermore, any direct quotation should then be restated in your own words in order that your instructor may evaluate your understanding of the material.

Failure to adhere to these standards may result in zero credit for the entire assignment.